In the twentieth century, the building annexed some frescoed rooms of the adjacent Palazzo Fava. Currently only one of these rooms belongs to the hotel as function and meeting room named the Camerino d'Europa. Here the Carracci brothers moved their first artistic steps, creating an authentic masterpiece considered one of their most valuable works. Furthermore another artist Donato Creti left his sign on a wall of this precious room with his “Hercules and Cerberus”, dated 1688. Other frescoes, representing the Myth of Phaeton, decorate the vault of I Carracci Restaurant. Art historians agree the author was probably a talented student of Lorenzo Sabbatini, a bolognese painter, follower of Parmigianino and Vasari, who worked in Bologna, in Florence for the Medici and in the Vatican City.
The palace finally discovers its hotel vocation: on February 15, 1912 the Grand Hotel Baglioni officially opened. The building had still a leading role, two years later: Filippo Tommaso Marinetti chose the hotel for his famous blitz-exhibition, showing the works of Giorgio Morandi, Severo Pozzati, Giacomo Vespignani, Osvaldo Licini and Mario Bacchelli. For this reason the Cafè Marinetti is named after the founding artist of Futurism.
In the following decades, the hotel became the Bolognese home of Hollywood and Cinecittà stars, as well as of all important celebrities visiting the city, including royals, writers, artists and politicians, whose traces of their stays are still preserved in the precious "golden book". More than a century of life for a hotel born in the heart of the city's cultural life.